Paul Rudd once again brought his signature “Paul Rudd Mac and Me” prank to the forefront, entertaining audiences and catching talk show host Conan O’Brien off guard during a recent episode of the “Conan O’Brien Needs A Friend” podcast. The enduring prank, which famously involves Rudd substituting a real movie clip with a bizarre scene from “Mac & Me,” was executed with characteristic humor and elaborate setup, keeping the comedy tradition alive for longtime fans and Conan’s surprised guests.
Paul Rudd Reprises the Mac and Me Gag on Conan’s Podcast
During his guest appearance on the show, Rudd attempted to introduce a fake clip from his film “Anaconda,” going into an overly detailed and humorous backstory to set up the moment. He told the hosts that his movie was adapted from a book and suggested that the next clip would reveal how his character gained the rights to the story, all while struggling to contain his laughter. As Rudd continued his setup, Conan O’Brien, along with co-hosts Sona Movsesian and Matt Gourley, began to recognize the familiar prank unfolding.
Anaconda was based on a book
Rudd’s antics left little doubt for Conan that the prank was underway. As the host watched the setup unravel, he broke in, saying,
This is the least you’ve ever tried,
showing both his amusement and his familiarity with Rudd’s recurring bit. Rudd admitted his discomfort with setting up the prank, stating,
it when I set it up
and
when I’m sitting watching.
Despite this playful tension, Conan joked about his expectation to be pranked by Rudd in the future, even in hypothetical scenarios.

The Enduring Appeal of the Mac and Me Prank
O’Brien described a future moment where even on his deathbed, he expects Rudd to find a way to bring back the infamous “Mac & Me” scene. Imagining a comedic hospital scenario, O’Brien explained:
You’ll come in to say, ‘Hi,’ and I know you’re going to do a thing where I’m kind of in and out, but I’m there, and I’m so happy to see you, and then you’re going to say, ‘I just got good news from your doctor. They did a scan, and they actually can’t find any of the disease in the area. Take a look at the scan.’ And it’s going to be that. And it’s going to make me really happy.
Rudd was touched by this imagined moment and responded with appreciation, noting the creativity of Conan’s scenario:
That, by the way, is a really great way to do it because you have the X-ray box lit up on the wall. I’ve thought of other scenarios and that’s way better.
Why the Paul Rudd Mac and Me Prank Remains Iconic
The ongoing tradition between Paul Rudd and Conan O’Brien highlights the comedian’s ability to keep humor fresh, even as the prank becomes an anticipated moment. The bit not only delights audiences but also demonstrates the special dynamic between a host and a recurring guest. As the “Paul Rudd Mac and Me” prank shows, a running joke executed with perfect timing and mutual respect continues to capture the imagination and laughter of viewers, ensuring that this oddball scene from “Mac & Me” remains a touchstone in late-night comedy lore.
With Rudd’s creative setups and Conan’s good-natured reactions, the prank’s legacy endures, hinting that future appearances may yet bring new variations and laughs for fans, the host, and co-hosts alike.

