Ryan Reynolds, known for playing Deadpool, has delivered a witty response just days after Neil Patrick Harris was announced as the voice of Deadpool in a new virtual reality game. The playful exchange draws extra attention as fans compare the two actors’ takes on the iconic Merc with a Mouth, highlighting the ongoing conversation around Ryan Reynolds responds to Neil Patrick Harris Deadpool VR.
Following the announcement that Neil Patrick Harris would lend his voice to Deadpool in the upcoming VR title, Reynolds released a humorous parody referencing Harris’s breakthrough role as Doogie Howser, M.D. In an 85-second video, Reynolds mimics Doogie’s famous desk-tapping monologue, while adopting a deliberately saccharine voiceover which contrasts with the original show’s lighthearted tone. The sitcom, popular in the late 1980s and early 1990s, helped launch Harris’s acting career.
The new Deadpool VR game, introduced during Summer Game Fest, has already generated buzz for both its casting choices and its polished combat system. Neil Patrick Harris heads the project as Deadpool, while Reynolds’s commentary ensures a strong link to the previous film adaptations. The announcement was covered by outlets like GamesRadar+, adding further excitement for fans eager to experience the character in a new immersive format.

In his skit, Reynolds launches into a tongue-in-cheek speech, stating,
“Today I learned a lesson about buttholes they don’t teach you in medical school,”
—Ryan Reynolds, Actor. He continues,
“People who steal your signature role are the biggest buttholes of all.”
—Ryan Reynolds, Actor. The playful jab is soon disrupted by Robyn Lively, best known for her role as Michele, Doogie’s love interest in the original series and the half-sister of actress Blake Lively.
Inside the Development and Features of Deadpool VR
Deadpool VR is being crafted by Twisted Pixel, with lead design manager Phil Therien eager to give players a faithful Deadpool experience. Therien explained the approach while speaking to GamesRadar+, emphasizing the game’s intent to capture every facet of the popular character.
“It’s really all about being the cool, all-encompassing Deadpool experience,”
—Phil Therien, Lead Design Manager, Twisted Pixel. Therien further remarked,
“He has the weapons, he’s got the wit, the humor, and his own trademark way to solve problems. We’ve got all that throughout our game, so really, we’ve been kind of bottled up like what it is like to be Deadpool in VR.”
—Phil Therien, Lead Design Manager, Twisted Pixel.
The game’s combat system and overall design have already impressed early viewers, with reviewers noting the dynamic action delivered through the Meta Quest 3 platform. While Deadpool VR has no official release date yet, anticipation continues to build thanks to its innovative approach and the involvement of well-known talents such as Harris and Reynolds.
Twisted Pixel, a studio with experience in inventive VR concepts, is handling development duties. The participation of GamesRadar+ and extensive coverage by fans and media outlets underscore the significant interest in how Neil Patrick Harris brings his own flavor to the role, distinct from both Reynolds and past animated adaptations.
What to Expect as Deadpool Expands in Gaming
The back-and-forth between Ryan Reynolds and Neil Patrick Harris adds a creative boost to the launch campaign for Deadpool VR. As other properties, such as the collaboration between Deadpool and Wolverine, continue to expand the Marvel universe, this new game illustrates how the character transcends film and television to embrace interactive media.
This playful exchange, along with commentary from notable names like Phil Therien, Neil Patrick Harris, and Ryan Reynolds, demonstrates that fans will find plenty of familiar wit and action in the upcoming title. With the game still awaiting a confirmed launch date for Meta Quest 3, dedicated Marvel and VR audiences can look forward to further updates as the release draws closer.